Echinocandin
Echinocandin is a class of antifungal drugs that inhibit the synthesis of beta-glucan, a component of the fungal cell wall. They are typically used to treat invasive fungal infections in patients who are immunocompromised or critically ill.
Mechanism of Action[edit | edit source]
Echinocandins work by inhibiting the enzyme 1,3-beta-D-glucan synthase, which is responsible for the synthesis of beta-glucan. This leads to a weakening of the fungal cell wall and ultimately, cell death.
Types of Echinocandins[edit | edit source]
There are currently three echinocandins approved for use:
Each of these drugs has a slightly different spectrum of activity and side effect profile, but all are effective against a range of Candida species and Aspergillus species.
Side Effects[edit | edit source]
Common side effects of echinocandins include:
More serious side effects can include liver damage and anaphylaxis, although these are rare.
Drug Interactions[edit | edit source]
Echinocandins can interact with a number of other medications, including cyclosporine, tacrolimus, and sirolimus. These interactions can increase the risk of side effects and should be managed carefully.
See Also[edit | edit source]
Echinocandin Resources | ||
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