Elongation factors
Elongation factors are a set of proteins that facilitate the synthesis of protein in ribosomes during the process of translation. They are part of the larger group of protein biosynthesis factors.
Function[edit | edit source]
Elongation factors play a crucial role in the elongation phase of protein biosynthesis. They assist in the synthesis of the polypeptide chain by adding amino acids to the growing chain. This process continues until a stop codon is reached on the mRNA molecule.
There are three main types of elongation factors:
- EF-Tu (or EF1 in eukaryotes): This factor binds to an aminoacyl-tRNA (a tRNA molecule with an amino acid attached) and brings it to the A site of the ribosome.
- EF-Ts (or EF1B in eukaryotes): This factor regenerates EF-Tu in bacteria after it has delivered its aminoacyl-tRNA to the ribosome.
- EF-G (or EF2 in eukaryotes): This factor promotes the translocation of the tRNA and mRNA down the ribosome at the end of each round of polypeptide elongation.
Role in Disease[edit | edit source]
Mutations in elongation factors can lead to various diseases. For example, mutations in the EF2 gene have been associated with cancer and neurodegenerative diseases.
See Also[edit | edit source]
References[edit | edit source]
| Elongation factors Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
