Endoglin

Endoglin is a type of glycoprotein that is primarily found on the surface of endothelial cells. It is a part of the TGF-beta receptor complex and has a crucial role in angiogenesis, the process of new blood vessel formation from pre-existing vessels. Mutations in the endoglin gene can lead to a rare genetic disorder known as Hereditary Hemorrhagic Telangiectasia (HHT).

Structure

Endoglin is a homodimeric membrane glycoprotein composed of two subunits linked by disulfide bonds. Each subunit has a large extracellular domain, a single transmembrane domain, and a short cytoplasmic tail. The extracellular domain is responsible for ligand binding, while the cytoplasmic tail is involved in signal transduction.

Function

Endoglin plays a critical role in the regulation of angiogenesis, a process that is essential for the growth and development of tissues and organs. It does this by modulating the activity of the TGF-beta receptor complex, which is involved in the regulation of cell proliferation, differentiation, and migration. In addition to its role in angiogenesis, endoglin is also involved in the regulation of inflammation and wound healing.

Clinical significance

Mutations in the endoglin gene can lead to Hereditary Hemorrhagic Telangiectasia (HHT), a rare genetic disorder characterized by the formation of abnormal blood vessels. Patients with HHT often suffer from recurrent nosebleeds, gastrointestinal bleeding, and may have arteriovenous malformations in various organs. Endoglin is also overexpressed in several types of cancer, including breast cancer, colorectal cancer, and renal cell carcinoma, and is therefore considered a potential target for cancer therapy.

See also

• TGF-beta
• Angiogenesis
• Hereditary Hemorrhagic Telangiectasia
• Glycoprotein

Endoglin Resources
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