Diloxanide

Diloxanide furoate

Diloxanide is an antiprotozoal medication primarily used to treat amoebiasis, an infection caused by the Entamoeba histolytica parasite. It is often administered in the form of its furoate salt, diloxanide furoate.

Medical Uses

Diloxanide is effective against the cyst form of Entamoeba histolytica, making it a valuable treatment for asymptomatic carriers of the parasite. It is typically used in combination with other medications, such as metronidazole, to treat both the cyst and trophozoite forms of the parasite. This combination therapy is particularly useful in treating both acute and chronic amoebiasis.

Mechanism of Action

The exact mechanism of action of diloxanide is not fully understood. However, it is believed to work by inhibiting the growth and reproduction of the amoeba, thereby reducing the number of cysts excreted in the feces and preventing the spread of the infection.

Side Effects

Common side effects of diloxanide include gastrointestinal disturbances such as nausea, vomiting, and abdominal pain. Less common side effects may include headache, dizziness, and skin rashes. It is generally well-tolerated, but patients with a history of hypersensitivity to the drug should avoid its use.

Contraindications

Diloxanide is contraindicated in individuals with known hypersensitivity to the drug. It should be used with caution in patients with liver disease or other severe illnesses. Pregnant and breastfeeding women should consult their healthcare provider before using diloxanide.

Dosage and Administration

The dosage of diloxanide varies depending on the age and weight of the patient, as well as the severity of the infection. It is usually taken orally, with or without food. The typical course of treatment lasts for 10 days, but the exact duration may vary based on the patient's response to the medication.

Related Pages

• Amoebiasis
• Entamoeba histolytica
• Metronidazole
• Antiprotozoal