Epoxomicin
Epoxomicin is a naturally occurring selective proteasome inhibitor with potential anticancer activity. It is derived from the Actinomycetes bacteria. Epoxomicin covalently binds to the 20S proteasome, a large protein complex that degrades unneeded or damaged proteins within the cell. This leads to an accumulation of polyubiquitinated proteins, which may cause cell cycle arrest, apoptosis, and inhibition of tumor growth.
Mechanism of Action[edit | edit source]
Epoxomicin works by covalently binding to the 20S proteasome, a large protein complex that degrades unneeded or damaged proteins within the cell. This binding inhibits the proteasome's proteolytic activity, leading to an accumulation of polyubiquitinated proteins. These proteins are typically marked for degradation by the proteasome. When they accumulate, they can disrupt cellular processes and lead to cell cycle arrest and apoptosis.
Potential Uses[edit | edit source]
Epoxomicin has potential anticancer activity. By inhibiting the proteasome, it can disrupt the growth of cancer cells and potentially lead to their death. It is currently being studied for its potential use in the treatment of various types of cancer.
Side Effects[edit | edit source]
As with any drug, epoxomicin may have side effects. These can include nausea, vomiting, and fatigue. More serious side effects can include blood disorders and liver damage. It is important for patients to discuss these potential side effects with their healthcare provider before starting treatment with epoxomicin.
See Also[edit | edit source]
| Epoxomicin Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
