Epstein–Barr virus-associated lymphoproliferative diseases

Epstein–Barr virus-associated lymphoproliferative diseases (EBV-LPDs) are a group of disorders in which the Epstein–Barr virus (EBV), a type of herpesvirus, causes an uncontrolled proliferation of lymphocytes, the white blood cells involved in the body's immune response. These diseases can range from benign to malignant and can affect both children and adults.

Etiology

EBV-LPDs are caused by the Epstein–Barr virus, a member of the herpesvirus family. This virus is very common and is transmitted primarily through saliva. Most people are infected with EBV at some point in their lives, but the virus usually remains dormant and does not cause symptoms. However, in some cases, the virus can reactivate and cause disease.

Clinical Presentation

The clinical presentation of EBV-LPDs can vary widely, depending on the specific disorder and the individual patient. Symptoms may include fever, fatigue, swollen lymph nodes, and in severe cases, organ dysfunction or failure.

Diagnosis

Diagnosis of EBV-LPDs typically involves a combination of clinical evaluation, laboratory testing, and imaging studies. Laboratory tests may include blood tests to detect the presence of the virus and to assess the function of the immune system. Imaging studies, such as computed tomography (CT) or magnetic resonance imaging (MRI), may be used to assess the extent of the disease.

Treatment

Treatment of EBV-LPDs depends on the specific disorder and the severity of the disease. Treatment options may include antiviral medications, immunosuppressive therapy, chemotherapy, and in some cases, stem cell transplantation.

Prognosis

The prognosis for patients with EBV-LPDs can vary widely, depending on the specific disorder and the individual patient's overall health. Some patients may experience a complete recovery, while others may have a chronic or relapsing course of disease.

See Also

• Epstein–Barr virus
• Lymphoproliferative disorders
• Herpesvirus
• Lymphocytes
• Immunosuppressive therapy
• Stem cell transplantation

References

Epstein–Barr virus-associated lymphoproliferative diseases Resources
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