Erbin (protein)

Protein ERBB2IP PDB 1mfg

Erbin (protein)

Erbin is a protein that plays a crucial role in various cellular processes. It is encoded by the ERBIN gene and is primarily found in the cytoplasm and cell membrane. Erbin is known to interact with several other proteins, forming complexes that are involved in cell signaling, cell adhesion, and cell polarity.

Structure

Erbin is a multi-domain protein consisting of several functional domains, including PDZ domains and LRR domains. These domains enable Erbin to interact with a wide range of partner proteins, allowing it to participate in diverse cellular functions.

Function

Erbin functions as a scaffold protein, bringing together different signaling molecules and coordinating their activities within the cell. It is involved in regulating cell proliferation, cell migration, and cell differentiation. Erbin also plays a role in maintaining cell polarity and adhesion.

Interactions

Erbin interacts with various proteins, including the E-cadherin complex, the ErbB2 receptor, and the Par3/Par6/aPKC complex. These interactions are essential for the proper functioning of Erbin and its involvement in different cellular processes.

Clinical Significance

Mutations in the ERBIN gene have been associated with certain diseases, including cancer. Dysregulation of Erbin expression or function can lead to abnormal cell growth and contribute to the development of tumors. Understanding the role of Erbin in disease pathogenesis may provide insights for potential therapeutic interventions.