Estrogen synthesis inhibitor

Estrogen Synthesis Inhibitors are a class of drugs that inhibit the synthesis of estrogen, a group of primary female sex hormones. They are often used in the treatment of hormone-sensitive cancers, such as certain types of breast cancer, and in assisted reproduction.

Mechanism of Action

Estrogen synthesis inhibitors work by blocking the action of aromatase, an enzyme that converts androgens to estrogens. This reduces the overall level of estrogen in the body, which can slow the growth of estrogen-dependent tumors.

Types of Estrogen Synthesis Inhibitors

There are several types of estrogen synthesis inhibitors, including:

• Aromatase inhibitors: These drugs directly inhibit the action of aromatase, reducing the conversion of androgens to estrogens. Examples include anastrozole, letrozole, and exemestane.

• Gonadotropin-releasing hormone (GnRH) agonists: These drugs inhibit the release of gonadotropin, a hormone that stimulates the ovaries to produce estrogen. Examples include leuprolide and goserelin.

Uses

Estrogen synthesis inhibitors are primarily used in the treatment of hormone-sensitive cancers, such as certain types of breast cancer. They may also be used in assisted reproduction to control the timing of ovulation.

Side Effects

Common side effects of estrogen synthesis inhibitors include hot flashes, joint pain, and fatigue. More serious side effects can include osteoporosis, heart disease, and stroke.

See Also

• Hormone therapy
• Breast cancer
• Ovarian cancer
• Endometrial cancer