Amitriptyline/perphenazine

Amitriptyline/Perphenazine

Amitriptyline/Perphenazine is a prescription medication used in the treatment of various mental health conditions. It is a combination of two drugs: amitriptyline, a tricyclic antidepressant, and perphenazine, a typical antipsychotic.

Indications

Amitriptyline/Perphenazine is primarily used to treat schizophrenia and bipolar disorder. It may also be used off-label for other conditions, such as major depressive disorder and anxiety disorders.

Mechanism of Action

Amitriptyline works by increasing the levels of certain chemicals in the brain that help improve mood, sleep, appetite, and energy level. Perphenazine works by blocking the action of dopamine, a neurotransmitter in the brain, which helps to reduce hallucinations and improve concentration.

Side Effects

Common side effects of Amitriptyline/Perphenazine include drowsiness, dizziness, dry mouth, constipation, and weight gain. Serious side effects may include increased heart rate, blurred vision, seizures, and suicidal thoughts.

Contraindications

Amitriptyline/Perphenazine should not be used in patients with a history of hypersensitivity to either amitriptyline or perphenazine, or in patients with certain heart conditions, liver disease, or glaucoma.

Interactions

Amitriptyline/Perphenazine may interact with other medications, including other antidepressants, antipsychotics, and certain heart medications. It is important to inform your healthcare provider of all medications you are currently taking.

Dosage and Administration

The dosage of Amitriptyline/Perphenazine is individualized based on the patient's condition and response to treatment. It is usually taken orally, once or twice daily.

See Also

• Tricyclic antidepressant
• Typical antipsychotic
• Schizophrenia
• Bipolar disorder