Extravasation

Extravasation refers to the leakage of any fluid or substance from its designated pathway or container into surrounding tissues. This term is commonly used in medical scenarios, describing phenomena such as the migration of white blood cells during inflammation or cancer cells during metastasis.

Mechanism and Contexts

• Inflammation: Extravasation in the context of inflammation denotes the movement of white blood cells, primarily leukocytes, from the capillaries to surrounding tissues. This process, also termed leukocyte extravasation or diapedesis, is a vital step in the immune response to infection or injury.

• Cancer Metastasis: Here, the term refers to malignant cancer cells migrating from capillaries, facilitating their spread to various organs.

• Urine and Blood Leakage: Extravasation can describe unintended urine or blood leakage from their usual pathways.

Extravasation in Surgical Procedures

Extravasation during medical procedures, especially surgeries, often involves unintended escape of fluids used during the procedure.

• Extravasation of Irrigation Fluid:
  • This pertains to the unintentional migration of irrigation fluids like saline, which are introduced during certain endoscopic surgeries. Examples of these surgeries include arthroscopy, TURP (trans-urethral resection of the prostate), and TCRE (trans-cervical resection of the endometrium).
  • In arthroscopy, pressurized fluid is used to inflate a joint, facilitating a clearer surgical view. However, especially in soft-tissue surrounded joints (like the shoulder or hip), fluid can leak out of the joint space, leading to potential complications such as edema or, in the case of hip arthroscopy, abdominal flooding.
  • Certain factors elevate the risk of fluid extravasation, including a lengthy procedure, age, obesity, and decreased muscle tone.
  • Tools like Extravastat devices can be employed during arthroscopy to drain extravasated fluid, minimizing swelling and procedure interference.

Extravasation of Infusates

Extravasation can also involve the escape of infused substances, like high-osmolarity solutions or chemotherapy agents, from blood vessels into subcutaneous tissue. Such leakage can lead to severe tissue damage and complications due to the caustic nature of some infusates.

Potential Complications

• Tissue Damage: Extravasation of caustic fluids can lead to tissue necrosis, which requires immediate medical attention.

• Swelling and Edema: Leakage of irrigation fluid can cause swelling, affecting surgical procedures or leading to potential airway obstructions.

• Abdominal Flooding: A concerning complication of hip arthroscopy where leaked irrigation fluid enters the abdominal cavity.

Management and Prevention

• Monitoring: Constant monitoring of infusion sites can help in early detection of extravasation.

• Pressure Control: Managing the pressure of infused or irrigated fluids can reduce the risk of extravasation.

• Quick Procedures: Reducing procedure time decreases the chances of fluid leakage, especially in surgeries like arthroscopy.

• Use of Specialized Tools: Instruments designed to drain extravasated fluid during surgeries can mitigate risks associated with fluid buildup.

See also

• Arthroscopy
• Intravasation
• Diapedesis
• Metastasis

Extravasation Resources
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