FGF23

FGF23 or Fibroblast Growth Factor 23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family, which is involved in a wide variety of biological processes, including cell growth, morphogenesis, tissue repair, tumor growth, and invasion.

Function

FGF23 is a hormone that regulates phosphate and vitamin D metabolism. It is produced in bone cells and acts on the kidney to increase phosphate excretion and decrease active vitamin D production. This hormone is also involved in the regulation of calcium and phosphorus levels in the body.

Clinical significance

Mutations in the FGF23 gene can lead to a number of disorders. These include autosomal dominant hypophosphatemic rickets (ADHR), a condition that affects the bones and teeth, and tumor-induced osteomalacia (TIO), a rare paraneoplastic syndrome characterized by the development of hypophosphatemia due to renal phosphate wasting.

In addition, elevated levels of FGF23 have been associated with chronic kidney disease (CKD). In CKD, the kidneys are unable to properly filter waste and excess substances from the blood, leading to a buildup of these substances, including phosphate. The body responds by increasing FGF23 production to promote phosphate excretion, but this can lead to a decrease in active vitamin D production and subsequent problems with bone health.

Research

Research into FGF23 has increased in recent years due to its potential role in various diseases. Studies are ongoing to better understand the regulation of FGF23 and its role in health and disease, with the hope of developing new treatments for conditions such as CKD and ADHR.

See also

• Fibroblast growth factor
• Phosphate homeostasis
• Vitamin D
• Chronic kidney disease
• Autosomal dominant hypophosphatemic rickets
• Tumor-induced osteomalacia