FG 7142

FG 7142 is a chemical compound that acts as a partial inverse agonist at the benzodiazepine site of the GABAA receptor. It is primarily used in scientific research to study the role of the GABAA receptor in various physiological and pathological processes.

Chemical Properties

FG 7142 is a member of the beta-carboline family, which are known for their interaction with the GABAA receptor. The chemical structure of FG 7142 allows it to bind to the benzodiazepine site on the GABAA receptor, but instead of enhancing the receptor's activity like typical benzodiazepines, it reduces the receptor's activity.

Pharmacology

FG 7142 exhibits anxiogenic (anxiety-producing) and pro-convulsant effects, which are opposite to the effects of benzodiazepines that are typically anxiolytic (anxiety-reducing) and anticonvulsant. This makes FG 7142 a useful tool in research for understanding the mechanisms of anxiety and seizure disorders.

Research Applications

FG 7142 is used in various research studies to investigate:

• The role of the GABAA receptor in anxiety and stress responses.
• The mechanisms underlying seizure activity and epilepsy.
• The effects of inverse agonists on the central nervous system.

Safety and Handling

As with many research chemicals, FG 7142 should be handled with care. It is important to follow appropriate safety protocols, including the use of personal protective equipment and working in a well-ventilated area.

Related Compounds

FG 7142 is related to other beta-carbolines and benzodiazepine receptor ligands, such as:

• Diazepam
• Flumazenil
• Beta-carboline

See Also

• GABAA receptor
• Benzodiazepine
• Anxiety
• Seizure
• Epilepsy

External Links

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