FOXK1

FOXK1 (Forkhead Box K1) is a protein that in humans is encoded by the FOXK1 gene. This protein belongs to the forkhead family of transcription factors which are characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not been determined; however, it has been shown to play a role in the regulation of muscle differentiation.

Function

FOXK1 is involved in the regulation of gene expression during the development and differentiation of skeletal muscle cells. It acts as a transcriptional activator or repressor depending on the context and interacts with a variety of cofactors to modulate the expression of target genes involved in muscle cell growth and differentiation. FOXK1 has also been implicated in the regulation of cell cycle progression and may play roles in other tissues and processes.

Gene

The FOXK1 gene is located on the long (q) arm of chromosome 7 at position 31.1, from base pair 117,481,031 to 117,715,971. The gene produces a 733 amino acid protein.

Clinical Significance

Alterations in the expression of FOXK1 have been associated with various types of cancer, including liver cancer and colorectal cancer. Its role in cancer appears to be complex and may involve the regulation of tumor cell proliferation, migration, and invasion. Additionally, due to its involvement in muscle differentiation, FOXK1 is a potential target for the development of therapies for muscle-related diseases or conditions.

Research

Research on FOXK1 continues to uncover its roles in different biological processes and diseases. Studies have focused on understanding its molecular mechanisms of action, its interaction with other proteins and genes, and its potential as a therapeutic target.