Factor II

Factor II, also known as prothrombin, is a protein produced by the liver and is one of the clotting factors that help the body to form blood clots. It is a precursor to thrombin, which plays a key role in the blood clotting process.

Function

Factor II is a part of the coagulation cascade, the process by which the body forms blood clots to seal off damage to blood vessels and prevent excessive bleeding. It is converted into its active form, thrombin, by the enzyme prothrombinase. Thrombin then acts to convert fibrinogen, another clotting factor, into fibrin, which forms the structure of a blood clot.

Factor II Deficiency

A deficiency in Factor II can lead to a bleeding disorder known as Factor II deficiency. This is a rare condition that can lead to excessive bleeding, bruising, and prolonged clotting times. It can be caused by a genetic mutation or can be acquired as a result of certain medical conditions or treatments.

Factor II Mutation

A mutation in the Factor II gene can lead to a condition known as Factor II mutation, or prothrombin G20210A mutation. This mutation increases the amount of prothrombin in the blood, which can increase the risk of developing abnormal blood clots.

Treatment

Treatment for conditions related to Factor II depends on the specific condition and its severity. For Factor II deficiency, treatment may involve Factor II concentrate or fresh frozen plasma to replace the missing Factor II. For Factor II mutation, treatment may involve anticoagulant medications to reduce the risk of blood clots.

See Also

• Coagulation
• Blood clot
• Hemostasis
• Factor II deficiency
• Factor II mutation

Factor II Resources
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