Factor vii

Factor VII (also known as serum prothrombin conversion accelerator or proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. A deficiency of factor VII is known as Factor VII deficiency.

Function

Factor VII (FVII) is one of the proteins that cause blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. The main role of factor VII (FVII) is to initiate the process of coagulation in conjunction with tissue factor (TF/factor III). Tissue factor is found on the outside of blood vessels - normally not exposed to the bloodstream. Upon vessel injury, tissue factor is exposed to the blood and circulating factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself.

Genetics

The GEN1 gene, located on the chromosome 13 (13q34), encodes the factor VII protein.

Clinical significance

Deficiency of factor VII, known as Factor VII deficiency, leads to a bleeding diathesis, and is treated with recombinant factor VIIa (NovoSeven).

See also

• Coagulation
• Factor VII deficiency
• Hemophilia

External links

• Factor VII at WikiMD

Factor vii Resources
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