Fasudil hydrochloride

Fasudil Hydrochloride is a Rho kinase inhibitor and vasodilator that is primarily used in the treatment of cerebral vasospasm and to manage symptoms of pulmonary hypertension. It is known for its ability to inhibit both the Rho-kinase enzyme and protein kinase.

Pharmacology

Fasudil Hydrochloride works by inhibiting the Rho-kinase enzyme, which is involved in the regulation of the shape and movement of cells. By inhibiting this enzyme, Fasudil Hydrochloride can prevent the constriction of blood vessels, thereby improving blood flow and reducing blood pressure.

Clinical Uses

Fasudil Hydrochloride is used in the treatment of cerebral vasospasm, a condition that occurs when blood vessels in the brain constrict, often following a subarachnoid hemorrhage. It is also used to manage symptoms of pulmonary hypertension, a condition characterized by high blood pressure in the arteries of the lungs.

Side Effects

Common side effects of Fasudil Hydrochloride include nausea, dizziness, and headache. In rare cases, it can cause more serious side effects such as hypotension (low blood pressure), arrhythmia (irregular heartbeat), and gastrointestinal bleeding.

Research

Research is ongoing into the potential use of Fasudil Hydrochloride in other conditions, including cancer, diabetes, and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

See Also

• Rho kinase
• Vasodilator
• Cerebral vasospasm
• Pulmonary hypertension