Fenprostalene

Fenprostalene

Fenprostalene is a synthetic prostaglandin analogue used primarily in veterinary medicine. It is a potent agent that mimics the effects of naturally occurring prostaglandins, which are lipid compounds that have diverse hormone-like effects in animals.

Chemical Structure and Properties

Fenprostalene is a member of the prostaglandin family, specifically designed to have a longer duration of action compared to natural prostaglandins. Its chemical structure is characterized by a prostaglandin skeleton with modifications that enhance its stability and efficacy.

• IUPAC Name: (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxy-13-methyl-5-propyl-1-oxoprost-13-en-1-yl acetate
• Molecular Formula: C24H34O5
• Molecular Weight: 402.52 g/mol

Mechanism of Action

Fenprostalene acts by binding to prostaglandin receptors in the body, leading to a series of physiological responses. It primarily affects the reproductive system, where it induces luteolysis, the breakdown of the corpus luteum, leading to a decrease in progesterone production. This action is crucial in synchronizing estrus in livestock.

Uses in Veterinary Medicine

Fenprostalene is used in veterinary practice for:

• Estrus Synchronization: It is used to control the timing of estrus in cattle, facilitating breeding programs.
• Induction of Parturition: Fenprostalene can be used to induce labor in pregnant animals, particularly in cattle and swine.
• Treatment of Pyometra: It helps in the treatment of uterine infections by promoting uterine contractions and expulsion of infected material.

Administration and Dosage

Fenprostalene is typically administered via subcutaneous injection. The dosage varies depending on the species and the intended use. It is important to follow veterinary guidelines and manufacturer instructions to ensure safe and effective use.

Side Effects and Precautions

While fenprostalene is generally safe when used as directed, it can cause side effects such as:

• Abdominal Discomfort: Animals may experience mild abdominal pain following administration.
• Diarrhea: Gastrointestinal disturbances are possible.
• Allergic Reactions: Rarely, animals may exhibit hypersensitivity to the drug.

Precautions should be taken to avoid accidental exposure to humans, as prostaglandins can cause adverse effects such as bronchospasm and uterine contractions.

Regulatory Status

Fenprostalene is approved for use in veterinary medicine in several countries. It is important to adhere to local regulations regarding its use and withdrawal times in food-producing animals.

Also see

• Prostaglandin
• Estrus synchronization
• Veterinary pharmacology
• Luteolysis