Ferumoxsil
| Ferumoxsil_structure.png Chemical structure of Ferumoxsil | |
Ferumoxsil is a superparamagnetic iron oxide used as an oral contrast agent in magnetic resonance imaging (MRI) of the gastrointestinal tract. It is marketed under the trade names Lumirem and Gastromark.
Mechanism of Action[edit | edit source]
Ferumoxsil consists of superparamagnetic iron oxide particles coated with a silicone layer. When ingested, these particles create a magnetic field that alters the local magnetic environment, enhancing the contrast of the gastrointestinal tract in MRI scans. This allows for better visualization of the bowel and surrounding structures.
Clinical Use[edit | edit source]
Ferumoxsil is primarily used in MRI to improve the visualization of the bowel. It is particularly useful in distinguishing between the bowel and other abdominal organs, which can be challenging due to the similar signal intensities of these tissues in standard MRI.
Administration[edit | edit source]
Ferumoxsil is administered orally. The typical dosage involves the patient drinking a suspension of the contrast agent prior to undergoing an MRI scan. The timing of administration is crucial to ensure optimal bowel coating and image contrast.
Safety and Side Effects[edit | edit source]
Ferumoxsil is generally well-tolerated. However, some patients may experience mild gastrointestinal discomfort, nausea, or diarrhea. As with any contrast agent, there is a risk of allergic reactions, although these are rare.
Pharmacokinetics[edit | edit source]
After oral administration, Ferumoxsil is not absorbed into the bloodstream but remains within the gastrointestinal tract. It is eventually excreted in the feces. The silicone coating prevents the iron oxide core from being absorbed, minimizing systemic exposure.
Regulatory Status[edit | edit source]
Ferumoxsil is approved for use in several countries, including the United States, where it is marketed under the brand name Gastromark.
Research and Development[edit | edit source]
Research is ongoing to explore the use of Ferumoxsil and similar agents in other imaging modalities and to improve the formulation for better patient compliance and image quality.
Also see[edit | edit source]
Template:Magnetic resonance imaging Template:Contrast agents
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