Fibroblast

Fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals.

Overview

Fibroblasts, which are derived from the mesenchyme, produce both fibers and ground substance of the extracellular matrix of the connective tissue. They are large, flat, elongated (spindle-shaped) cells possessing processes extending out from the ends of the cell body. The cell nucleus is flat and oval or elongated, often with a small nucleolus.

Function

Fibroblasts produce the structural framework for tissues, which includes the extracellular matrix and collagen. They play a crucial role in wound healing, as they migrate to the site of injury where they deposit new collagen and facilitate the healing process.

Role in Wound Healing

During the process of wound healing, fibroblasts proliferate and migrate to the site of injury, where they secrete extracellular matrix precursors and facilitate the formation of a new tissue layer. This process is crucial for wound healing and the restoration of tissue integrity.

Fibroblast in Disease

Fibroblasts play a role in many diseases, including fibrosis, where excessive fibroblast proliferation leads to the formation of fibrous tissue, impairing the function of the organ or tissue. They are also implicated in the development of cancer, as they can contribute to the formation of a supportive stroma that aids tumor growth.

See Also

• Extracellular matrix
• Collagen
• Wound healing
• Fibrosis
• Cancer

References

Fibroblast Resources
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