Fladrafinil

A eugeroic drug related to adrafinil

Fladrafinil, also known as CRL-40,941, is a eugeroic drug that is chemically related to adrafinil and modafinil. It is known for its wakefulness-promoting effects and has been studied for its potential use in treating sleep disorders and enhancing cognitive function.

Chemical Structure and Properties

Chemical structure of Fladrafinil

Fladrafinil is a bis(p-fluoro) derivative of adrafinil, which means it has two additional fluorine atoms compared to adrafinil. This modification is believed to enhance its potency and effectiveness. The chemical structure of fladrafinil is characterized by the presence of a sulfinyl group, which is also found in modafinil and adrafinil.

Pharmacology

Fladrafinil acts as a central nervous system stimulant. It is thought to work by increasing the levels of certain neurotransmitters in the brain, such as dopamine and norepinephrine, which are associated with alertness and wakefulness. The exact mechanism of action is not fully understood, but it is believed to involve the inhibition of dopamine reuptake, similar to modafinil.

Uses

Fladrafinil is primarily used for its wakefulness-promoting effects. It has been studied for potential applications in treating conditions such as narcolepsy, shift work sleep disorder, and obstructive sleep apnea. Additionally, it is sometimes used off-label as a cognitive enhancer, although its safety and efficacy for this purpose are not well-established.

Side Effects

The side effects of fladrafinil are similar to those of other eugeroic drugs. Common side effects may include headache, nausea, anxiety, and insomnia. Due to its stimulant properties, it may also increase heart rate and blood pressure. Long-term use and high doses can lead to more serious side effects, and its safety profile is not fully understood.

Legal Status

The legal status of fladrafinil varies by country. In some regions, it is classified as a research chemical and is not approved for medical use. In others, it may be available by prescription for specific medical conditions. It is important to check local regulations before purchasing or using fladrafinil.

Related Compounds

Fladrafinil is closely related to other eugeroic drugs such as adrafinil and modafinil. These compounds share similar mechanisms of action and are used for similar purposes. However, the presence of additional fluorine atoms in fladrafinil may alter its pharmacokinetic properties and potency.

Related pages

• Adrafinil
• Modafinil
• Eugeroic
• Narcolepsy