Flurazepam hydrochloride

Flurazepam Hydrochloride is a benzodiazepine derivative drug used for the treatment of insomnia. It is known for its hypnotic properties and is primarily used for short-term treatment of acute insomnia and relief from sleep onset or sleep maintenance problems.

Pharmacology[edit | edit source]

Flurazepam hydrochloride acts on the GABA receptor, enhancing the effects of the neurotransmitter GABA (gamma-aminobutyric acid). This results in sedative, anxiolytic, muscle relaxant, and anticonvulsant properties. The drug is metabolized in the liver and excreted primarily in the urine.

Medical Uses[edit | edit source]

Flurazepam hydrochloride is used for the short-term treatment of insomnia, including difficulties in falling asleep, frequent awakening, early awakenings, and insomnia related to anxiety and stress. It is not recommended for long-term use due to the risk of dependence and withdrawal symptoms.

Side Effects[edit | edit source]

Common side effects of flurazepam hydrochloride include drowsiness, dizziness, and loss of coordination. Less common side effects can include confusion, depression, and memory impairment. Long-term use can lead to dependence and withdrawal symptoms upon discontinuation.

Contraindications[edit | edit source]

Flurazepam hydrochloride is contraindicated in patients with known hypersensitivity to benzodiazepines, severe respiratory insufficiency, sleep apnea syndrome, and severe hepatic insufficiency.

Interactions[edit | edit source]

Flurazepam hydrochloride can interact with other medications, including other CNS depressants, certain antibiotics, antifungal agents, and antiretroviral drugs. It is important to inform healthcare providers of all medications being taken to avoid potential interactions.