Fonsecaea pedrosoi

A comprehensive overview of Fonsecaea pedrosoi

Overview

Fonsecaea pedrosoi under a microscope

Fonsecaea pedrosoi is a fungus that is primarily known for causing the chronic skin infection known as chromoblastomycosis. This organism is a dematiaceous fungus, meaning it has darkly pigmented hyphae and spores, which contribute to its characteristic appearance under the microscope.

Taxonomy

Fonsecaea pedrosoi belongs to the kingdom Fungi, the phylum Ascomycota, and the class Dothideomycetes. It is part of the order Chaetothyriales and the family Herpotrichiellaceae.

Morphology

The fungus is characterized by its slow growth and the production of dark, velvety colonies. Microscopically, Fonsecaea pedrosoi exhibits septate hyphae and conidia that are arranged in short chains or clusters. The conidia are typically brown due to the presence of melanin, which is thought to protect the fungus from environmental stresses.

Pathogenesis

Fonsecaea pedrosoi is a primary pathogen in chromoblastomycosis, a chronic cutaneous and subcutaneous mycosis. The infection is typically acquired through traumatic implantation of the fungus into the skin, often via thorns or splinters. The disease is characterized by the development of verrucous lesions, which can become extensive and disfiguring if left untreated.

Epidemiology

Chromoblastomycosis caused by Fonsecaea pedrosoi is most commonly found in tropical and subtropical regions, particularly in rural areas where individuals are more likely to come into contact with contaminated soil and plant material. The disease is more prevalent in Central America, South America, and parts of Africa and Asia.

Diagnosis

Diagnosis of infection with Fonsecaea pedrosoi is typically made through clinical examination and laboratory testing. Direct microscopy of skin scrapings or biopsy specimens can reveal the characteristic sclerotic bodies, also known as "copper pennies." Culture of the organism on appropriate media can confirm the diagnosis.

Treatment

Treatment of chromoblastomycosis caused by Fonsecaea pedrosoi can be challenging. Antifungal therapy, often with agents such as itraconazole or terbinafine, is commonly used. In some cases, surgical excision of lesions may be necessary. Early diagnosis and treatment are crucial to prevent complications and improve outcomes.

Prevention

Preventive measures include wearing protective clothing and footwear to reduce the risk of skin trauma in endemic areas. Public health education and awareness can also help reduce the incidence of infection.

Related pages

• Chromoblastomycosis
• Fungal infection
• Ascomycota