Isoflurane

Isoflurane

Isoflurane is a type of halogenated ether commonly used for inhalational anesthesia. It is a colorless, volatile liquid that has a sweet, pungent odor. Isoflurane is often used in both human and veterinary medicine due to its rapid onset and smooth recovery period.

History

Isoflurane was first synthesized in the 1960s by Ross Terrell and J.F. Nunn, two British chemists. It was introduced to clinical practice in 1971, and quickly gained popularity due to its favorable properties.

Pharmacology

Isoflurane is a general anesthetic that works by depressing the central nervous system, causing unconsciousness and a lack of sensation. It is thought to work by enhancing the activity of gamma-aminobutyric acid (GABA) receptors in the brain, although the exact mechanism is not fully understood.

Isoflurane is administered through inhalation, and is rapidly taken up by the lungs. It is then distributed throughout the body via the bloodstream. Isoflurane is largely metabolized by the liver, with a small amount excreted unchanged in the breath.

Clinical Use

Isoflurane is used in a variety of surgical procedures, including cardiac surgery, neurosurgery, and pediatric surgery. It is also used in veterinary medicine, particularly for small animal surgery.

Isoflurane has a number of advantages over other anesthetics. It has a rapid onset and recovery, and is less likely to cause nausea and vomiting post-operatively. However, it can cause a drop in blood pressure and may be unsuitable for patients with certain heart conditions.

Safety and Side Effects

Like all anesthetics, isoflurane has potential side effects. These can include nausea, vomiting, and a drop in blood pressure. Rarely, it can cause malignant hyperthermia, a potentially life-threatening reaction.

See Also

• Anesthesia
• Halogenated ether
• General anesthetic
• Inhalational anesthesia