Formestane

Formestane

Formestane is a type of steroidal aromatase inhibitor that is primarily used in the treatment of breast cancer. It is classified as an antiestrogen due to its mechanism of action, which involves inhibiting the enzyme aromatase, thereby reducing the production of estrogen in the body. Formestane is often used in postmenopausal women, where it can help to slow the growth of certain types of breast tumors that require estrogen to grow.

History

Formestane was first developed in the 1980s and was one of the first aromatase inhibitors to be used in the treatment of breast cancer. It was initially marketed under the brand name Lentaron.

Mechanism of Action

Formestane works by binding to the enzyme aromatase, which is responsible for converting androgens into estrogens. By inhibiting this enzyme, formestane reduces the overall levels of estrogen in the body. This is particularly useful in the treatment of estrogen-receptor positive breast cancer, as these types of tumors require estrogen to grow.

Side Effects

Like all medications, formestane can cause side effects. The most common side effects include hot flashes, nausea, and fatigue. Less common side effects can include hair loss, joint pain, and depression.

Pharmacokinetics

Formestane is administered via intramuscular injection. It is rapidly absorbed into the bloodstream and has a half-life of approximately 5 days. It is metabolized in the liver and excreted in the urine.

See Also

• Aromatase inhibitor
• Breast cancer
• Estrogen
• Antiestrogen