Foscenvivint

Foscarnet is an antiviral drug used in the treatment of cytomegalovirus retinitis (CMV retinitis), a disease that can occur in patients with AIDS. It is also used to treat herpes simplex virus (HSV) and varicella zoster virus (VZV) infections, when these viruses are resistant to other antiviral drugs.

Mechanism of Action

Foscarnet works by inhibiting the DNA polymerase of CMV and HSV, preventing the virus from replicating its DNA and thus inhibiting its ability to reproduce and infect other cells.

Side Effects

Common side effects of foscarnet include nausea, vomiting, diarrhea, headache, and fatigue. More serious side effects can include kidney damage, seizures, and anemia.

Administration

Foscarnet is administered intravenously, usually in a hospital setting due to the potential for serious side effects and the need for close monitoring of the patient's condition.

Resistance

Resistance to foscarnet can occur, particularly in patients with advanced HIV infection who have been previously treated with other antiviral drugs. Resistance is usually due to mutations in the DNA polymerase gene of the virus.

See Also

• Antiviral drug
• Cytomegalovirus retinitis
• Herpes simplex virus
• Varicella zoster virus