Fosnetupitant chloride hydrochloride
Fosnetupitant chloride hydrochloride is a pharmacological agent used in the prevention of chemotherapy-induced nausea and vomiting. It is a member of the neurokinin-1 (NK1) receptor antagonists class of drugs.
Pharmacology[edit | edit source]
Fosnetupitant chloride hydrochloride acts as an antagonist at the neurokinin-1 (NK1) receptor, a G-protein coupled receptor found in the brain and peripheral tissues. The NK1 receptor is the primary receptor for substance P, a neuropeptide involved in a variety of physiological processes, including pain perception and the emetic reflex. By blocking the action of substance P at the NK1 receptor, fosnetupitant chloride hydrochloride can prevent chemotherapy-induced nausea and vomiting.
Clinical Use[edit | edit source]
Fosnetupitant chloride hydrochloride is used in combination with other antiemetic agents for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. It is also used for the prevention of nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy.
Side Effects[edit | edit source]
Common side effects of fosnetupitant chloride hydrochloride include fatigue, constipation, and hiccups. Less common side effects can include dizziness, diarrhea, and abdominal pain. As with all medications, patients should be monitored for any adverse reactions.
See Also[edit | edit source]
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