Fremanezumab
Monoclonal antibody for migraine prevention
| Fremanezumab | |
|---|---|
| |
| INN | |
| Drug class | Monoclonal antibody |
| Routes of administration | |
| Pregnancy category | |
| Bioavailability | |
| Metabolism | |
| Elimination half-life | |
| Excretion | |
| Legal status | |
| CAS Number | |
| PubChem | |
| DrugBank | |
| ChemSpider | |
| KEGG | |
Fremanezumab, sold under the brand name Ajovy, is a monoclonal antibody used for the prevention of migraines. It is specifically designed to target and inhibit the activity of the calcitonin gene-related peptide (CGRP), a molecule involved in migraine pathophysiology.
Mechanism of Action[edit | edit source]
Fremanezumab works by binding to the CGRP ligand, thereby preventing it from interacting with its receptor. CGRP is a neuropeptide that plays a crucial role in the transmission of pain and the development of migraine headaches. By inhibiting CGRP, fremanezumab reduces the frequency and severity of migraine attacks.
Clinical Use[edit | edit source]
Fremanezumab is indicated for the preventive treatment of migraine in adults. It is administered via subcutaneous injection and can be given either as a monthly dose or a quarterly dose, depending on the patient's needs and the prescribing physician's recommendation.
Side Effects[edit | edit source]
Common side effects of fremanezumab include injection site reactions, such as pain, redness, and swelling. Some patients may also experience hypersensitivity reactions. It is important for patients to discuss any adverse effects with their healthcare provider.
Development and Approval[edit | edit source]
Fremanezumab was developed by Teva Pharmaceuticals and received approval from the U.S. Food and Drug Administration (FDA) in September 2018. It was one of the first CGRP inhibitors to be approved for migraine prevention, marking a significant advancement in the treatment of this condition.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
