Frovatriptan succinate

Frovatriptan succinate is a triptan drug developed by Endo Pharmaceuticals and used for the treatment of migraine headaches. It is a selective 5-HT1 receptor agonist.

Pharmacology

Frovatriptan succinate works by stimulating serotonin (5-HT_1D) receptors located in the brain, which causes the muscles surrounding the blood vessels in the brain to contract and narrow the blood vessels. At the same time, it also reduces inflammatory substances in the body that can trigger head pain, nausea, sensitivity to light and sound, and other migraine symptoms.

Clinical Use

Frovatriptan is used to treat the symptoms of migraine headaches (severe, throbbing headaches that sometimes are accompanied by nausea and sensitivity to sound and light). Frovatriptan is in a class of medications called selective serotonin receptor agonists. It works by narrowing blood vessels in the brain, stopping pain signals from being sent to the brain, and blocking the release of certain natural substances that cause pain, nausea, and other symptoms of migraine.

Side Effects

Common side effects of frovatriptan succinate include dizziness, flushing, dry mouth, upset stomach, chest pain, heavy feeling, pain or a tight feeling in your jaw, neck, or throat, weakness, stomach pain or discomfort, and mild headache (not a migraine).

Precautions

Before taking frovatriptan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

See Also

• Triptan
• Migraine
• 5-HT1 receptor
• Endo Pharmaceuticals