GFRα1

GFRα1 (GDNF family receptor alpha-1) is a protein that in humans is encoded by the GFRA1 gene. It is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF (glial cell line-derived neurotrophic factor) and NRTN (neurturin).

Function[edit | edit source]

GFRα1 is a receptor for GDNF and NRTN, which are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The GDNF-GFRα1 interaction is a part of a complex system of multiple ligands and receptors with potential implications for neural development.

Clinical significance[edit | edit source]

Mutations in the GFRA1 gene have been associated with Hirschsprung disease (HSCR). HSCR is a congenital disorder characterized by absence of enteric neurons along variable lengths of the colon resulting in intestinal obstruction.

Interactions[edit | edit source]

GFRα1 has been shown to interact with RET.

References[edit | edit source]

External links[edit | edit source]

GFRA1 at the US National Library of Medicine Medical Subject Headings (MeSH)

GFRα1 Resources
Need Help Finding a Doctor? Need help finding a doctor or specialist anywhere in the world? Explore our world directory. WikiMD's DocFinder can assist you in locating millions of physicians.	Medical Knowledge Access the latest research - Most recent articles Ongoing trials.