GPSM1

Ideogram human chromosome 9

GPSM1

GPSM1, also known as G-protein signaling modulator 1, is a protein-coding gene located on chromosome 1 in humans. It plays a crucial role in regulating G-protein signaling pathways within cells.

Function

GPSM1 functions as a modulator of G-protein signaling by interacting with Gα subunits and regulating their activity. This protein is involved in various cellular processes, including cell proliferation, differentiation, and migration.

Structure

The GPSM1 gene encodes a protein that consists of multiple domains, including a regulator of G-protein signaling (RGS) domain and a GoLoco motif. These domains enable GPSM1 to interact with Gα subunits and modulate their signaling activity.

Clinical Significance

Mutations in the GPSM1 gene have been associated with certain diseases, such as cancer and neurological disorders. Dysregulation of G-protein signaling pathways due to GPSM1 mutations can lead to abnormal cell behavior and disease progression.

Interactions

GPSM1 interacts with various proteins involved in G-protein signaling pathways, including Gα subunits and other modulators of G-protein signaling. These interactions are essential for the proper regulation of cellular responses to extracellular stimuli.