GRASP55
GRASP55[edit | edit source]
GRASP55 (Golgi Reassembly Stacking Protein of 55 kDa) is a protein that plays a crucial role in the Golgi apparatus structure and function. It is involved in the stacking of Golgi cisternae and is essential for maintaining the integrity of the Golgi structure during the cell cycle.
Structure[edit | edit source]
GRASP55 is characterized by its unique domain structure, which includes a PDZ domain and a GRASP domain. These domains are critical for its function in Golgi stacking and membrane tethering. The PDZ domain allows GRASP55 to interact with other proteins, while the GRASP domain is involved in membrane attachment.
Function[edit | edit source]
GRASP55 is primarily involved in the reassembly of the Golgi apparatus after mitosis. During cell division, the Golgi apparatus disassembles and then reassembles in the daughter cells. GRASP55, along with its homolog GRASP65, facilitates this reassembly process by mediating the stacking of Golgi cisternae.
Role in Golgi Apparatus[edit | edit source]
The Golgi apparatus is a central organelle in the secretory pathway of eukaryotic cells. It is responsible for modifying, sorting, and packaging proteins and lipids for secretion or delivery to other organelles. GRASP55 contributes to the structural organization of the Golgi by promoting the stacking of its cisternae, which is essential for its function.
Cellular Processes[edit | edit source]
GRASP55 is involved in various cellular processes beyond Golgi stacking. It plays a role in protein trafficking, cell signaling, and autophagy. Its function in autophagy is particularly important under stress conditions, where it helps in the formation of autophagosomes.
Interactions[edit | edit source]
GRASP55 interacts with several proteins, including GM130, a Golgi matrix protein, and Rab GTPases, which are involved in vesicle trafficking. These interactions are crucial for its role in Golgi reassembly and function.
Related pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
