GREB1

GREB1 (Gene Regulated in Breast Cancer 1) is a gene that is highly expressed in estrogen receptor-positive breast cancer. It is a critical mediator of estrogen signaling and plays a significant role in the growth and progression of breast cancer.

Function

GREB1 is a gene that is regulated by the hormone estrogen. It is a critical mediator of estrogen signaling, which is a key pathway in the development and progression of breast cancer. The GREB1 gene produces a protein that interacts with the estrogen receptor, enhancing its activity and promoting the growth of cancer cells.

Role in Breast Cancer

In estrogen receptor-positive breast cancer, the GREB1 gene is often overexpressed, meaning it produces more protein than normal. This overexpression can lead to increased growth and proliferation of cancer cells. Studies have shown that inhibiting the activity of the GREB1 gene can slow the growth of breast cancer cells, suggesting that it may be a potential target for cancer therapy.

Clinical Significance

The clinical significance of GREB1 is currently being investigated in several areas. It has been identified as a potential biomarker for predicting response to estrogen therapy in breast cancer patients. Additionally, drugs that target the GREB1 gene are being developed as potential treatments for estrogen receptor-positive breast cancer.

Research

Research into the role of GREB1 in breast cancer is ongoing. Current studies are focused on understanding the exact mechanisms by which GREB1 promotes cancer growth and developing drugs that can inhibit its activity.

File:GREB1 gene location.png

Location of the GREB1 gene on chromosome 2

See Also

• Breast Cancer
• Estrogen Receptor
• Gene Therapy
• Cancer Therapy