GSK-649868

From WikiMD's Wellness Encyclopedia

GSK-649868 is an experimental drug that was developed by GlaxoSmithKline for the treatment of insomnia. It acts as a selective antagonist for the orexin receptor, specifically the OX2 subtype, and has sedative effects.

Pharmacology[edit | edit source]

GSK-649868 is a selective antagonist for the orexin receptor, specifically the OX2 subtype. Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. By blocking the action of orexin, GSK-649868 promotes sleep.

Clinical trials[edit | edit source]

GSK-649868 has undergone Phase II clinical trials for the treatment of insomnia. However, as of 2021, it has not been approved for use by any regulatory authority.

See also[edit | edit source]

References[edit | edit source]

GSK-649868 Resources
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Contributors: Prab R. Tumpati, MD