GYKI-52895

GYKI-52895 is a non-competitive antagonist at the AMPA receptor, a type of ionotropic glutamate receptor in the brain. It is part of the 2,3-benzodiazepine compound class and has been used in scientific research to help understand the function and pharmacology of AMPA receptors.

Pharmacology

GYKI-52895 acts by inhibiting the action of glutamate at the AMPA receptor, thereby reducing the flow of ions through the receptor channel. This results in a decrease in neuronal excitability, which can have various effects depending on the specific brain region where the drug is active.

Uses in Research

Due to its specific action on AMPA receptors, GYKI-52895 has been used in a variety of research contexts. For example, it has been used to study the role of AMPA receptors in neurological disorders such as epilepsy and Alzheimer's disease. It has also been used to investigate the potential therapeutic effects of AMPA receptor antagonists in these and other conditions.

Chemistry

GYKI-52895 is a member of the 2,3-benzodiazepine compound class. These compounds are characterized by a benzene ring fused to a diazepine ring, with the specific structure of the diazepine ring varying among different compounds in the class.

See Also

• AMPA receptor
• Glutamate
• 2,3-benzodiazepine
• Neurological disorders

References

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