GYKI 52895
GYKI 52895 is a non-competitive antagonist at the AMPA receptor, a type of ionotropic glutamate receptor in the brain. It is part of the 2,3-benzodiazepine class of compounds, which are known for their potential in treating neurological disorders such as epilepsy and anxiety.
Pharmacology[edit | edit source]
GYKI 52895 acts by inhibiting the action of glutamate, the primary excitatory neurotransmitter in the brain, at the AMPA receptor. This inhibition is non-competitive, meaning that GYKI 52895 does not compete with glutamate for the same binding site on the receptor. Instead, it binds to a separate site, altering the receptor's conformation and reducing its responsiveness to glutamate.
Therapeutic Potential[edit | edit source]
Due to its action on the AMPA receptor, GYKI 52895 has been investigated for its potential in treating various neurological and psychiatric disorders. These include epilepsy, where it may help to reduce the frequency and severity of seizures, and anxiety, where it may help to reduce symptoms by decreasing excessive neuronal excitation.
Research[edit | edit source]
Research into GYKI 52895 and related compounds has provided valuable insights into the workings of the AMPA receptor and the role of glutamate in the brain. This has implications not only for the treatment of neurological and psychiatric disorders, but also for our understanding of normal brain function.
See Also[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD