G protein-coupled receptor kinase 7

G protein-coupled receptor kinase 7 (GRK7) is a protein that in humans is encoded by the GRK7 gene. This protein is part of the G protein-coupled receptor kinase (GRK) family, which plays a crucial role in the regulation of G protein-coupled receptor (GPCR) signaling pathways.

Function

GRK7 is primarily expressed in the retina, where it is involved in the desensitization of rhodopsin, a GPCR that is activated by light and initiates the visual signal transduction pathway. By phosphorylating activated rhodopsin, GRK7 contributes to the rapid recovery of the light response, allowing the retina to adapt to different light conditions.

Structure

The GRK7 protein consists of 553 amino acids and has a molecular weight of approximately 63 kDa. It contains a central kinase domain that is responsible for its catalytic activity, as well as a regulator of G protein signaling (RGS) domain that is thought to interact with GPCRs.

Clinical significance

Mutations in the GRK7 gene have been associated with a form of congenital stationary night blindness, indicating a crucial role of this kinase in visual function. Moreover, altered expression levels of GRK7 have been observed in certain types of cancer, suggesting a potential role in tumorigenesis.

See also

• G protein-coupled receptor kinase
• G protein-coupled receptor
• Rhodopsin
• Congenital stationary night blindness

External links

• GRK7 at the National Center for Biotechnology Information

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