Gadolinium neutron-capture therapy

Gadolinium Neutron-Capture Therapy

Gadolinium, a rare earth metal used in neutron-capture therapy

Gadolinium Neutron-Capture Therapy (GdNCT) is a type of radiotherapy that uses the neutron-capturing properties of the rare earth element gadolinium to destroy cancer cells. This therapy is a promising alternative to traditional radiation therapy and chemotherapy for the treatment of various types of cancer.

Mechanism of Action

In GdNCT, gadolinium-157 (157Gd), the most abundant and neutron-absorbing isotope of gadolinium, is used. When 157Gd captures a neutron, it undergoes a nuclear reaction that produces gamma rays and high-energy electrons. These particles can cause significant damage to nearby cancer cells.

Clinical Applications

GdNCT has been studied for the treatment of various types of cancer, including brain tumors, breast cancer, and melanoma. The therapy has shown promise in preclinical studies, but further research is needed to determine its efficacy and safety in humans.

Advantages and Challenges

One of the main advantages of GdNCT is its potential for targeted therapy. Because gadolinium can be attached to tumor-specific antibodies, it can be delivered directly to cancer cells, minimizing damage to healthy tissue. However, there are also challenges associated with GdNCT, including the need for a neutron source and the potential for toxicity from gadolinium.

See Also

• Neutron capture therapy of cancer
• Boron neutron capture therapy
• Radiation therapy
• Chemotherapy