Gallamine

Gallamine is a non-depolarizing muscle relaxant. It acts by blocking the effects of acetylcholine at the neuromuscular junction. Gallamine has a tri-ethiodide ion, which is responsible for its muscle relaxant properties.

Pharmacology

Gallamine works by binding to the acetylcholine receptors at the neuromuscular junction, thereby inhibiting the action of acetylcholine. This results in muscle relaxation. The drug has a rapid onset of action and a short duration of effect.

Uses

Gallamine is used in anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Side Effects

Possible side effects of gallamine include hypotension, tachycardia, and increased salivation. It may also cause an increase in intraocular pressure, making it unsuitable for use in patients with glaucoma.

Contraindications

Gallamine is contraindicated in patients with known hypersensitivity to the drug. It should also be used with caution in patients with myasthenia gravis, as it may exacerbate the condition.

Interactions

Gallamine may interact with other drugs such as antibiotics, calcium channel blockers, and magnesium sulfate, which may enhance its neuromuscular blocking effects.

See Also

• Neuromuscular-blocking drug
• Acetylcholine receptor

Gallamine Resources
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