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Gestonorone acetate is a progestin medication which is used in gynecology and obstetrics. It is also known as gestronol hexanoate and is sold under the brand name Depostat among others. It is administered by intramuscular injection and is not available in oral form.

Pharmacology

Gestonorone acetate is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has strong progestogenic activity and weak antiandrogen and antigonadotropic effects.

Medical uses

Gestonorone acetate is used in the treatment of gynecological disorders such as menorrhagia, endometriosis, and uterine fibroids. It is also used in the treatment of prostate cancer.

Side effects

The side effects of gestonorone acetate are similar to those of other progestins. They can include menstrual irregularities, breast tenderness, nausea, headache, and fluid retention.

History

Gestonorone acetate was first described in the literature in 1960 and was introduced for medical use by 1962.

See also

• List of progestogens
• List of progestogen esters

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