Gintuit

Gintuit is a cell-based product used in regenerative medicine, specifically for the treatment of oral soft tissue injuries. It is a living, bioengineered tissue graft designed to promote the healing of gingival (gum) tissue. Gintuit is composed of human cells, including keratinocytes and fibroblasts, which are cultured on a scaffold to create a tissue-like structure.

Development and Approval

Gintuit was developed by Organogenesis, a company specializing in regenerative medicine. The product received approval from the United States Food and Drug Administration (FDA) in 2012 for use in dental and periodontal procedures. The approval was based on clinical trials demonstrating its safety and efficacy in promoting the regeneration of gingival tissue.

Composition

Gintuit is composed of:

• Keratinocytes: These are the primary cells found in the epidermis, the outermost layer of the skin. In Gintuit, they help form the outer layer of the graft.
• Fibroblasts: These cells are responsible for producing collagen and other extracellular matrix components, providing structural support to the tissue.
• Scaffold: A biocompatible material that supports the growth and organization of the cells into a tissue-like structure.

Mechanism of Action

Gintuit works by providing a living tissue graft that integrates with the patient's existing gingival tissue. The keratinocytes and fibroblasts in Gintuit produce growth factors and extracellular matrix proteins that promote tissue regeneration and healing. This helps to restore the structure and function of damaged or diseased gingival tissue.

Clinical Applications

Gintuit is primarily used in the following clinical applications:

• Periodontal surgery: To treat gum recession and other periodontal defects.
• Dental implants: To enhance the healing and integration of dental implants.
• Oral surgery: To repair soft tissue defects resulting from trauma or surgical procedures.

Advantages

The use of Gintuit offers several advantages:

• Reduced healing time: The living cells in Gintuit promote faster tissue regeneration.
• Improved outcomes: Gintuit can lead to better aesthetic and functional results compared to traditional grafting techniques.
• Minimally invasive: The use of Gintuit can reduce the need for harvesting tissue from other parts of the patient's body.

Related Pages

• Regenerative medicine
• Periodontology
• Dental implant
• Tissue engineering
• Organogenesis

See Also

• Keratinocyte
• Fibroblast
• Scaffold (tissue engineering)
• Periodontal surgery
• Oral surgery