Globose nucleus

Globose nucleus is a part of the brainstem that plays a significant role in the motor system. It is one of the four deep cerebellar nuclei, lying within the white matter of the cerebellum.

Anatomy

The globose nucleus is located medially in the cerebellum, adjacent to the fastigial nucleus. It is one of the deep cerebellar nuclei, which also include the dentate nucleus, emboliform nucleus, and fastigial nucleus. These nuclei receive inhibitory inputs from the Purkinje cells of the cerebellar cortex and excitatory inputs from the cerebellar peduncles.

Function

The globose nucleus, along with the emboliform nucleus, forms the interposed nucleus. This nucleus is responsible for the unconscious proprioception of the body and plays a crucial role in the fine-tuning of motor movements, particularly those involving the distal muscles of the limbs.

Clinical significance

Damage to the globose nucleus can result in a variety of motor disorders, including ataxia, dysmetria, and tremor. These symptoms are often seen in conditions such as stroke, multiple sclerosis, and cerebellar degeneration.

See also

• Cerebellum
• Deep cerebellar nuclei
• Interposed nucleus
• Motor system

References

Globose nucleus Resources
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