Glyburide

Glyburide is an oral diabetes medication that helps control blood sugar levels. It is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Glyburide is not for treating type 1 diabetes.

Mechanism of Action

Glyburide lowers blood glucose by stimulating the release of insulin from the pancreas. It binds to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, depolarization of the membrane, influx of calcium through voltage-sensitive calcium channels, and increased fusion of insulin granules with the cell membrane.

Side Effects

Common side effects of glyburide include nausea, heartburn, feeling full, joint or muscle pain, and blurred vision. Serious side effects may include allergic reactions, dark urine, yellowing of the skin or eyes (jaundice), and easy bruising or bleeding.

Interactions

Glyburide may interact with other medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, and miconazole. It is important to inform your healthcare provider about all the medications you are currently taking.

Precautions

Before taking glyburide, tell your doctor if you have kidney disease, liver disease, or a G6PD deficiency. Also, inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding.

Dosage

The dosage of glyburide is individualized on the basis of both effectiveness and tolerance while not exceeding the maximum recommended dose of 20 mg daily.

See Also

• Diabetes mellitus type 2
• Insulin
• Sulfonylurea

Glyburide Resources
Latest articles Most recent articles Ongoing trials	Wikipedia