Glycoprotein 100

Glycoprotein 100 (also known as GP100) is a protein that is encoded by the PMEL gene in humans. It is a type I membrane protein and a member of the melanoma-associated antigen family. GP100 is involved in the formation of melanosomes, which are the organelles where melanin is synthesized and stored.

Function

GP100 plays a crucial role in the structural formation of melanosomes. It is involved in the maturation of melanosomes from stage I to stage II. The protein is also believed to regulate melanosome biogenesis and the structural organization of premelanosomes.

Clinical significance

GP100 is a significant tumor antigen in melanoma. It is recognized by T cells, which are a type of white blood cell that play a central role in cell-mediated immunity. The recognition of GP100 by T cells can lead to an immune response against melanoma cells. This has led to the development of cancer immunotherapy strategies that target GP100.

See also

• Melanoma
• Melanosome
• Tumor antigen
• Cancer immunotherapy

External links

• Glycoprotein 100 at UniProt

Glycoprotein 100 Resources
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