Glycoprotein 100
Glycoprotein 100 (also known as GP100) is a protein that is encoded by the PMEL gene in humans. It is a type I membrane protein and a member of the melanoma-associated antigen family. GP100 is involved in the formation of melanosomes, which are the organelles where melanin is synthesized and stored.
Function[edit | edit source]
GP100 plays a crucial role in the structural formation of melanosomes. It is involved in the maturation of melanosomes from stage I to stage II. The protein is also believed to regulate melanosome biogenesis and the structural organization of premelanosomes.
Clinical significance[edit | edit source]
GP100 is a significant tumor antigen in melanoma. It is recognized by T cells, which are a type of white blood cell that play a central role in cell-mediated immunity. The recognition of GP100 by T cells can lead to an immune response against melanoma cells. This has led to the development of cancer immunotherapy strategies that target GP100.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- Glycoprotein 100 at UniProt
| Glycoprotein 100 Resources | |
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Contributors: Prab R. Tumpati, MD
