Estrone tetraacetylglucoside

Estrone tetraacetylglucoside is a synthetic estrogen that is used in hormone replacement therapy. It is a derivative of estrone, one of the three main naturally occurring estrogens, the other two being estradiol and estriol.

Chemistry

Estrone tetraacetylglucoside is a glucoside of estrone. It is synthesized by acetylating the hydroxyl groups of estrone and then attaching a glucose molecule. The acetylation of the hydroxyl groups increases the lipophilicity of the molecule, which can enhance its absorption and bioavailability.

Pharmacology

Estrone tetraacetylglucoside acts as an estrogen by binding to the estrogen receptor. This binding can stimulate the growth of certain tissues, such as the endometrium, and can also have effects on the central nervous system, cardiovascular system, and bone.

Clinical use

Estrone tetraacetylglucoside is used in hormone replacement therapy to treat symptoms of menopause, such as hot flashes and vaginal dryness. It can also be used to prevent osteoporosis in postmenopausal women.

Side effects

Like other estrogens, estrone tetraacetylglucoside can have side effects. These can include nausea, bloating, breast tenderness, and an increased risk of certain types of cancer, such as breast cancer and endometrial cancer.

See also

• Estrone
• Estrogen
• Hormone replacement therapy
• Menopause
• Osteoporosis