Graham-Little-Piccardi-Lassueur syndrome
Alternate names[edit | edit source]
Graham Little-Piccardi-Lassueur syndrome; Graham Little syndrome; Piccardi-Lassueur-Little syndrome
Definition[edit | edit source]
Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare type of scarring hair loss.
Epidemiology[edit | edit source]
It is most commonly found in otherwise healthy women between the ages of 30 and 70 years.
Cause[edit | edit source]
The cause of this condition is not known; however, over the years, researchers have suggested theories that it may develop in relation to genetic factors, viral exposures, hormonal changes, immune system issues, stress, and vitamin deficiencies.
Signs and symptoms[edit | edit source]
- LPLS is characterized by three features: progressive patchy scarring hair loss of the scalp (cicatricial alopecia), non-scarring thinning of the hair in the armpits and groin (noncicatricial alopecia), and spiky rough bumps based around hair follicles (follicular lichen planus).
- Sometimes individuals with GLPLS experience itching around affected areas, which can be severe.
Clinical presentation[edit | edit source]
For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed. 80%-99% of people have these symptoms Alopecia(Hair loss)
- Perifollicular hyperkeratosis
- Sparse axillary hair(Limited armpit hair)
- Sparse pubic hair(Decreased sexual hair)
- Sparse scalp hair(Reduced/lack of hair on scalp)
30%-79% of people have these symptoms
- Lichenification
- Pruritus(Itching)
Diagnosis[edit | edit source]
- Routine investigation, including hemogram, blood sugar, renal and liver function tests, and thyroid function test were within normal limits.
- A biopsy from the scalp revealed features of scarring alopecia with dermis replaced by fibrous tissue with perifollicular and junctional lichenoid infilterate.
- Based on the above findings, a diagnosis of Graham Little-Piccardi-Lassueur syndrome was made.[1][1].
Treatment[edit | edit source]
Treatment focuses on slowing the progression of hair loss and may include corticosteroids, retinoids (medications related to vitamin A), psoralen plus ultraviolet light A (PUVA), antimalarial medications, and antibiotics.
References[edit | edit source]
- ↑ Pai, V. V., Kikkeri, N. N., Sori, T., & Dinesh, U. (2011). Graham-little piccardi lassueur syndrome: an unusual variant of follicular lichen planus. International journal of trichology, 3(1), 28–30. https://doi.org/10.4103/0974-7753.82129
NIH genetic and rare disease info[edit source]
Graham-Little-Piccardi-Lassueur syndrome is a rare disease.
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