GroES

GroES is a protein that in humans is encoded by the GroES gene. It is a molecular chaperone that works in conjunction with GroEL protein in assisting the folding of many proteins.

Function

GroES is a co-chaperonin that assists the chaperonin GroEL in protein folding. The GroES/GroEL system is essential in proteostasis, maintaining protein homeostasis within the cell. GroES and GroEL are part of the HSP60 family of molecular chaperones.

Structure

GroES is a single domain protein composed of seven identical subunits that form a ring structure. Each subunit is composed of a highly conserved 97 amino acid sequence. The ring structure formed by the seven subunits of GroES interacts with the GroEL complex, forming a football-shaped structure.

Clinical significance

Mutations in the GroES gene have been associated with various diseases, including spastic paraplegia and mitochondrial disease. Further research is needed to fully understand the role of GroES in these diseases.

See also

• GroEL
• Molecular chaperone
• Protein folding
• HSP60

External links

• GroES at UniProt

GroES Resources
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