HBG1
HBG1 is a gene that encodes the gamma-globin protein, which is a component of fetal hemoglobin. This gene is part of the beta globin gene cluster on chromosome 11, which also includes the genes for beta-globin, delta-globin, and epsilon-globin. The HBG1 gene is primarily expressed during fetal development, and its expression decreases after birth.
Function[edit | edit source]
The HBG1 gene provides instructions for making a protein called gamma-globin. This protein combines with another protein called alpha-globin to form fetal hemoglobin. Fetal hemoglobin is the primary form of hemoglobin in a developing fetus, and it has a higher affinity for oxygen than the adult form of hemoglobin. This allows the fetus to extract oxygen from the mother's bloodstream more efficiently.
Clinical significance[edit | edit source]
Mutations in the HBG1 gene can cause conditions such as hereditary persistence of fetal hemoglobin (HPFH) and beta thalassemia. HPFH is a condition in which fetal hemoglobin production continues into adulthood. Beta thalassemia is a blood disorder that reduces the production of hemoglobin.
See also[edit | edit source]
- Beta globin gene cluster
- Hemoglobinopathy
- Hereditary persistence of fetal hemoglobin
- Beta thalassemia
References[edit | edit source]
External links[edit | edit source]
- HBG1 at the National Center for Biotechnology Information
HBG1 Resources | ||
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