HBG1

HBG1 is a gene that encodes the gamma-globin protein, which is a component of fetal hemoglobin. This gene is part of the beta globin gene cluster on chromosome 11, which also includes the genes for beta-globin, delta-globin, and epsilon-globin. The HBG1 gene is primarily expressed during fetal development, and its expression decreases after birth.

Function

The HBG1 gene provides instructions for making a protein called gamma-globin. This protein combines with another protein called alpha-globin to form fetal hemoglobin. Fetal hemoglobin is the primary form of hemoglobin in a developing fetus, and it has a higher affinity for oxygen than the adult form of hemoglobin. This allows the fetus to extract oxygen from the mother's bloodstream more efficiently.

Clinical significance

Mutations in the HBG1 gene can cause conditions such as hereditary persistence of fetal hemoglobin (HPFH) and beta thalassemia. HPFH is a condition in which fetal hemoglobin production continues into adulthood. Beta thalassemia is a blood disorder that reduces the production of hemoglobin.

See also

• Beta globin gene cluster
• Hemoglobinopathy
• Hereditary persistence of fetal hemoglobin
• Beta thalassemia

External links

• HBG1 at the National Center for Biotechnology Information

HBG1 Resources
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