HBG2
HBG2
The HBG2 gene, also known as Hemoglobin Subunit Gamma 2, is a gene that is located on the human chromosome 11. It is one of the two genes that encode the gamma subunit of fetal hemoglobin.
Function[edit | edit source]
The HBG2 gene is primarily expressed in the fetal liver, spleen and bone marrow. It encodes the gamma-G globin gene, which is a component of fetal hemoglobin. Fetal hemoglobin is present in fetuses and infants, and is replaced by adult-type hemoglobin after birth. The switch from fetal to adult hemoglobin is a complex process and is regulated by the locus control region (LCR) located upstream of the globin gene cluster.
Clinical significance[edit | edit source]
Mutations in the HBG2 gene can lead to conditions such as hereditary persistence of fetal hemoglobin (HPFH) and beta thalassemia, which are disorders that affect the body's ability to produce hemoglobin. In HPFH, individuals have elevated levels of fetal hemoglobin into adulthood, which can help to mitigate the symptoms of beta thalassemia.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
- HBG2 at the National Center for Biotechnology Information
| HBG2 Resources | |
|---|---|
|
 |
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
