HCP5
HCP5 (HLA Complex P5) is a gene that in humans is encoded by the HCP5 gene. It is located on the short (p) arm of chromosome 6 at position 21. This gene is part of the Major Histocompatibility Complex (MHC) class I molecules, which are involved in the presentation of foreign antigens to the immune system.
Function[edit | edit source]
The HCP5 gene is involved in the immune response. It is thought to play a role in the presentation of viral antigens to the immune system. The protein encoded by this gene is a non-classical MHC class I molecule, which means it does not present antigens in the same way as classical MHC class I molecules. Instead, it is thought to present viral antigens in a way that is recognized by certain immune cells, leading to an immune response.
Clinical significance[edit | edit source]
Variations in the HCP5 gene have been associated with susceptibility to HIV infection and progression to AIDS. A specific variant of the HCP5 gene, known as rs2395029, is associated with a slower progression to AIDS in individuals infected with HIV. This variant is also associated with a lower viral load in individuals infected with HIV.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD