HIST1H2AE
From WikiMD's Wellness Encyclopedia
HIST1H2AE
HIST1H2AE is a gene that encodes a member of the histone H2A family. Histones are proteins that play a crucial role in packaging DNA into chromatin, which is essential for the regulation of gene expression and maintenance of genomic stability.
Function[edit | edit source]
The protein encoded by HIST1H2AE is a core component of nucleosomes, the basic repeating units of chromatin. Nucleosomes consist of DNA wrapped around histone proteins, including histone H2A, forming a structure that helps compact and organize the genetic material within the cell.
Role in Gene Regulation[edit | edit source]
Histone proteins, including HIST1H2AE, can undergo various post-translational modifications that influence chromatin structure and gene expression. These modifications can either promote or inhibit the accessibility of DNA to transcription factors and other regulatory proteins, thereby influencing gene activity.
Clinical Significance[edit | edit source]
Aberrant expression or mutations in genes encoding histone proteins like HIST1H2AE have been associated with various human diseases, including cancer. Dysregulation of histone modifications can lead to altered gene expression patterns, contributing to the development and progression of cancer and other disorders.
References[edit | edit source]
 | This gene article is a stub. You can help WikiMD by expanding it. |
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.